AustralieFrV1, Main, Exploration, bibRecord, 008170

Parity and Carotid Atherosclerosis in Men and Women : Insights Into the Roles of Childbearing and Child-Rearing

Identifieur interne : 008170 ( Main/Exploration ); précédent : 008169; suivant : 008171

Parity and Carotid Atherosclerosis in Men and Women : Insights Into the Roles of Childbearing and Child-Rearing

Auteurs : Michael R. Skilton [Australie, France] ; André Serusclat [France] ; Lisa M. Begg [Australie] ; Philippe Moulin [France] ; Fabrice Bonnet [France]

Source :

Stroke : (1970) [ 0039-2499 ] ; 2009.

RBID : Pascal:09-0183813

Descripteurs français

Pascal (Inist)
- Athérosclérose, Pathologie du système nerveux, Pathologie cérébrovasculaire, Accident cérébrovasculaire, Parité, Carotide, Homme, Enfant.
Wicri :
- topic : Homme, Enfant.

English descriptors

KwdEn :
- Atherosclerosis, Carotid, Cerebrovascular disease, Child, Human, Nervous system diseases, Parity, Stroke.

Abstract

Background and Purpose-Parity appears to be associated with carotid atherosclerosis in women aged 45 years and older. Studying this association among younger women and men may provide insight into whether this association relates predominantly to childbearing or child-rearing. Methods-The association between parity and carotid atherosclerosis (intima-media thickness and presence of plaques) was assessed in a cohort consisting of 750 women and 1164 men, all with at least one traditional cardiovascular risk factor, aged 18 to 80 years of age. Traditional cardiovascular risk factors were also assessed, and the Framingham Risk Score calculated. Results-In age-adjusted analyses, the number of children was associated with adiposity, fasting glucose, 2-hour glucose, Framingham risk score, and carotid atherosclerosis in women, but not in men. Multivariate linear regression models indicate that the prevalence of plaques was increased by 15% (95% CI, 2 to 29) per child among women, and 0% (95% CI, -10 to 11) among men, after adjustment for age, socioeconomic and lifestyle factors (including waist circumference). The association between parity and carotid intima-media thickness was similar in younger and older women (P_{Heterogeneity}=0.20). Conclusions-A higher number of children is associated with increased carotid atherosclerosis in both younger and older women, but not among men. These findings indicate that childbearing, but not child-rearing, may be a risk factor for atherosclerosis, and suggest the potential importance of considering the number of children when assessing the level of cardiovascular risk in women.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 002E66
to stream PascalFrancis, to step Curation: 003154
to stream PascalFrancis, to step Checkpoint: 002946
to stream Main, to step Merge: 008915
to stream Main, to step Curation: 008170

Le document en format XML

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<author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Parity and Carotid Atherosclerosis in Men and Women : Insights Into the Roles of Childbearing and Child-Rearing</title>
<author><name sortKey="Skilton, Michael R" sort="Skilton, Michael R" uniqKey="Skilton M" first="Michael R." last="Skilton">Michael R. Skilton</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Baker IDI Heart & Diabetes Institute</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA; Université Claude Bernard Lyon 1</s1>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
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<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
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</author>
<author><name sortKey="Serusclat, Andre" sort="Serusclat, Andre" uniqKey="Serusclat A" first="André" last="Serusclat">André Serusclat</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hospices Civils de Lyon Fédération d'Endocrinologie, Hôpital Cardiovasculaire</s1>
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</affiliation>
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<author><name sortKey="Begg, Lisa M" sort="Begg, Lisa M" uniqKey="Begg L" first="Lisa M." last="Begg">Lisa M. Begg</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Obstetrics & Gynecology Royal Women's Hospital</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
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<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
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</affiliation>
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<author><name sortKey="Moulin, Philippe" sort="Moulin, Philippe" uniqKey="Moulin P" first="Philippe" last="Moulin">Philippe Moulin</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>INSERM U870, IFR62</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
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<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>INRA, UMR1235</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>INSA-Lyon, RMND</s1>
<s2>Villeurbanne</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Villeurbanne</settlement>
<settlement type="city" wicri:auto="agglo">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Université Lyon 1, Faculté de Médecine Lyon Sud</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Medicine Endocrinology unit, CHU Rennes, Université Rennes 1, INSERM U625</s1>
<s2>Rennes</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Stroke : (1970)</title>
<title level="j" type="abbreviated">Stroke : (1970)</title>
<idno type="ISSN">0039-2499</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Stroke : (1970)</title>
<title level="j" type="abbreviated">Stroke : (1970)</title>
<idno type="ISSN">0039-2499</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atherosclerosis</term>
<term>Carotid</term>
<term>Cerebrovascular disease</term>
<term>Child</term>
<term>Human</term>
<term>Nervous system diseases</term>
<term>Parity</term>
<term>Stroke</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Athérosclérose</term>
<term>Pathologie du   système nerveux</term>
<term>Pathologie cérébrovasculaire</term>
<term>Accident cérébrovasculaire</term>
<term>Parité</term>
<term>Carotide</term>
<term>Homme</term>
<term>Enfant</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Enfant</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Background and Purpose-Parity appears to be associated with carotid atherosclerosis in women aged 45 years and older. Studying this association among younger women and men may provide insight into whether this association relates predominantly to childbearing or child-rearing. Methods-The association between parity and carotid atherosclerosis (intima-media thickness and presence of plaques) was assessed in a cohort consisting of 750 women and 1164 men, all with at least one traditional cardiovascular risk factor, aged 18 to 80 years of age. Traditional cardiovascular risk factors were also assessed, and the Framingham Risk Score calculated. Results-In age-adjusted analyses, the number of children was associated with adiposity, fasting glucose, 2-hour glucose, Framingham risk score, and carotid atherosclerosis in women, but not in men. Multivariate linear regression models indicate that the prevalence of plaques was increased by 15% (95% CI, 2 to 29) per child among women, and 0% (95% CI, -10 to 11) among men, after adjustment for age, socioeconomic and lifestyle factors (including waist circumference). The association between parity and carotid intima-media thickness was similar in younger and older women (P<sub>Heterogeneity</sub>
=0.20). Conclusions-A higher number of children is associated with increased carotid atherosclerosis in both younger and older women, but not among men. These findings indicate that childbearing, but not child-rearing, may be a risk factor for atherosclerosis, and suggest the potential importance of considering the number of children when assessing the level of cardiovascular risk in women.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
<li>Région Bretagne</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Lyon</li>
<li>Melbourne</li>
<li>Rennes</li>
<li>Villeurbanne</li>
</settlement>
</list>
<tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Skilton, Michael R" sort="Skilton, Michael R" uniqKey="Skilton M" first="Michael R." last="Skilton">Michael R. Skilton</name>
</region>
<name sortKey="Begg, Lisa M" sort="Begg, Lisa M" uniqKey="Begg L" first="Lisa M." last="Begg">Lisa M. Begg</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Skilton, Michael R" sort="Skilton, Michael R" uniqKey="Skilton M" first="Michael R." last="Skilton">Michael R. Skilton</name>
</region>
<name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
<name sortKey="Moulin, Philippe" sort="Moulin, Philippe" uniqKey="Moulin P" first="Philippe" last="Moulin">Philippe Moulin</name>
<name sortKey="Moulin, Philippe" sort="Moulin, Philippe" uniqKey="Moulin P" first="Philippe" last="Moulin">Philippe Moulin</name>
<name sortKey="Moulin, Philippe" sort="Moulin, Philippe" uniqKey="Moulin P" first="Philippe" last="Moulin">Philippe Moulin</name>
<name sortKey="Moulin, Philippe" sort="Moulin, Philippe" uniqKey="Moulin P" first="Philippe" last="Moulin">Philippe Moulin</name>
<name sortKey="Serusclat, Andre" sort="Serusclat, Andre" uniqKey="Serusclat A" first="André" last="Serusclat">André Serusclat</name>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Parity and Carotid Atherosclerosis in Men and Women : Insights Into the Roles of Childbearing and Child-Rearing

Parity and Carotid Atherosclerosis in Men and Women : Insights Into the Roles of Childbearing and Child-Rearing

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri